tuberculosis Pathogenesis and immunity

Despite the tuberculosis Pathogenesis and immunity development of curative chemotherapy, tuberculosis (TB) causes increased morbidity worldwide and is the leading cause of death of people in developing countries.

Recent advances in molecular genetics, bacterial immunology and human genetics insight into the molecular determinants of virulence, immune responses, which are for the limitation of disease progression, and determinants provided immunopathology of tuberculosis. Despite this progress, there is a large knowledge gap still that the development and testing of new interventions, including new drugs and effective vaccines is limited. This review focuses on the current understanding of the pathogenesis and immunity of TB derived in vitro and in vivo. Also highlights the problems that understood better, better control of the media tuberculosis must be to offer the world.

tuberculosis Pathogenesis and immunity

Phagocytosis by antigen-presenting cells of tubercle bacilli in human pulmonary alveoli a complex process of infection with Mycobacterium tuberculosis and potentially protective immune response of the host. M. tuberculosis has the features that you to can discover latent or progressive infection of success in most infected persons devoted much of its genome. The failure of the immune-mediated clearance adopted due to M. tuberculosis microbicides several strategies that block different mechanisms of infected immune cells and the formation of various granulomatous lesions that assist in their ability or suppress the persistence of the viability of M. tuberculosis. In this document, the current understanding of the various immunological processes, spread on the establishment of a latent infection with M. tuberculosis, the bacteria, persistence, and reactivation decline or elimination of latent infection and new diagnostic approaches used to people with latent infection for possible control of the TB epidemic are identified as described.
Tuberculosis (TB), one of the oldest human inclinations detected, is still a major cause of death from infectious diseases, despite the worldwide use of live attenuated vaccine and several antibiotics. New vaccines and drugs are needed to stem the global epidemic of tuberculosis kills two million people a year. Rational development of new TB agents, it is important to study the genetics and physiology of M. tuberculosis and related mycobacteria. Equally important is the interaction of M. tuberculosis-host learn to understand, to get around this cause bacterial host defense and diseases. The approaches in this paper of M. tuberculosis genes, or are potentially involved in virulence are described identified. In the future, some of these genes and the proteins they encode, and the recently discovered should a new bacterial targets that can be used selectively for the production of vaccines, tuberculosis Pathogenesis and immunity pharmaceuticals and diagnostic reagents.

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