tuberculosis granuloma treatment

One key feature of the immune response to M. tuberculosis is the tuberculosis granuloma treatment formation of an organized structure called a granuloma. It consists mainly of macrophage recruitment to the stage of infection, the cells are highly differentiated and multinucleated giant cells, epithelial cells and foam cells, these cells are surrounded by a circle of lymphocytes.

tuberculosis granuloma treatment

Although in the first instance granuloma bacillus infection reduces certain acts can survive even in the structure of a long time of inactivity. For some reason, you are not yet clear, basil reactivated in 10% of people with latent infection, escape from the granuloma and spread throughout the body, causing clinical disease, and eventually spread throughout the neighborhood. In the evaluation for the formation of granulomatous structures, and various types of cells have shown that the part of the inflammatory response are discussed. It also discusses a variety of in vivo and in vitro models available to study the structure of this fascinating immunity.

tuberculosis granuloma treatment

Background. Shorter regimens for the treatment of pulmonary tuberculosis (TB) is needed to facilitate. Their total eradication of long-term treatment is required for recurrence, suspected to be an outbreak of infection than the rest of the features encountered in granulomas occur.
Method. The literature was evaluated in clinical trials of adjuvant immunotherapy to identify. TB and other studies of the relationship between immune status and relapse of tuberculosis or reactivation
Results. Four studies of interferon therapy showed their inability to improve the ability of lung macrophages effectively mycobactericidal. A placebo-controlled trial of interleukin-2 therapy microbiology say random delayed response to treatment, while two-controlled anti-tumor necrosis factor (TNF) therapy (high-dose prednisolone and etanercept [a soluble TNF receptor test]) showed that this intervention response to significantly speed up the treatment. Four retrospective studies in which the response to treatment and / or accelerated risk of relapse in individuals coinfected with human immunodeficiency virus decreased identified; one study reported that immune reconstitution syndrome associated with an increased risk of recurrence. with the use of anti-retroviral therapy Some studies indicate that granulomas can be targeted and disrupted by anti-TNF antibody infliximab, tuberculosis granuloma treatment
apparently due to its ability to bind to cell surface TNF and induces apoptosis in cells that TNF efficient.

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