tuberculosis granuloma pathology
July 18, 2014
TB granulomas. Nucleated giant cells (mature – Langhans type): 50-100 microns, tuberculosis granuloma pathology
a large number of small cores (via 20) arranged on the periphery of the cell (or crown horseshoe), abundant eosinophilic cytoplasm. Occurs when activated macrophages fused. Long, with clear eosinophilic (pink) cytoplasm and central smooth ovoid nuclei: epithelioid cells activated macrophages resembling epithelial cells.
He sketches together and form aggregates. On the outskirts are lymphocytes (T cells), and plasma cells are rare, and fibroblasts. Cheesy eosinophilic necrosis, smooth, centrally located amorphous (pink). When fresh, the nuclear fragments may contain. Caseum is the result of giant cells and epithelial cell damage. (Hematoxylin-eosin, X20 ob)
tuberculosis granuloma pathology of human
Granuloma - a focal collection of inflammatory cells to sites of infection and tissue including activated macrophages (epithelial cells) Langhans giant cells ", and lymphocytes. Cheesy Necrosis - Regions with granular eosinophilic granuloma and brittle (cheese) necrotic cell debris Granulomatous inflammation - the characteristic pattern of chronic inflammatory reaction characterized by focal accumulation of activated macrophages (epithelioid histiocytes)
During infection of tuberculosis (TB), defined granulomas, where the micro-T-cell-specific antigens and activated colocate infected macrophages inhibit growth of Mycobacterium tuberculosis. Although granuloma is the site for murder virulent mycobacteria mycobacteria have different mechanisms mediated refuses developed. It’s death by macrophages Mycobacteria survive dormant, but if the host cellular immunity or structure damage signal granulomas mycobacteria maintain or resume replication, allowing reactivation of tuberculosis. This balance is very important not only apply to the mycobacteria, but also host macrophages, which can undergo apoptosis or necrosis, so that the characteristics of the cheese-like necrosis in granulomas, and the possible spread of tuberculosis infection. tuberculosis granuloma pathology Immune factors that influence the development and maintenance of granulomas control will be assessed.