Epstein Barr Virus
November 9, 2016
Epstein Barr Virus is the most common virus that has infected human in all over the world. Almost 95 percent of human get infected with EBV. Fortunately, this virus doesn’t cause severe symptoms for human. The symptoms are similar with influenza disease such as fever, fatigue, etc that will cure by itself. Sometimes just a few days, sometimes need months. Anyway, this Epstein Barr virus is suspected to be related with several carcinoma. About 200,000 cancer everyyear are attributable to EBV.
Epstein Barr virus is the member of herpes family virus. It is human herpes virus 4. Herpes family has eight type of herpes virus. Infectious mononucleosis was mostly caused by EBV. Infectious mononucleosis also known as glandular fever. According to some research, Epstein barr virus was associated with Hodgkin lymphoma, Burkitt’s lymphoma, gastric cancer, nasopharyngeal carcinoma. It is also associated with certain autoimmune disease, particularly dermatomyositis, SLE, rheumatoid arthritis, and multiple sclerosis.
Epstein Barr Virus often spread through saliva. It could be through kissing. That’s why infectious mononucleosis also known as kissing disease. So, if see the culture of the western country in where kissing by lips is very common, probably this is very fast to spread to other people.
Epstein Barr Virus Structure
Epstein Barr Virus is circle in form. It is about 122 nm to 180 nm in diameter. It is composed of double helix of DNA about 172 kilo basepairs. There is about 85 genes inside. Protein nucleocapsid covers the DNA. A tegument which is made by protein as well covers the nucleocapsid. Outer from the tegument, there is an envelope containing lipids and glycoprotein.
There are two types of Epstein Barr Virus. EBV type 1 and EBV type 2. Type 1 is dominant all over the world. But type 2 is most available in Africa. The difference is in EBNA-3 genes. It makes difference in the character of transforming capabilities and reactivation ability. How to differ this two type? It can be distinguished by cutting the viral genome with a restriction enzyme and comparing the resulting digestion patterns by gel electrophoresis.