Epstein barr virus, chronic fatigue syndrome

Epstein barr virus, chronic fatigue syndrome, What is the relationship? First, we need to define what is the definition of Chronice fatigue syndrome (CFS). CFS is a debilitating and complex disorder characterized by intense fatigue that is not improved by bed rest and that may be worsened by physical activity or mental exertion.
The other name of Chronic fatigue syndrome are myalgic encephalomyelitis (ME) and, more recently, systemic exertion intolerance disease (SEID).The cause of chronic fatigue syndrome is still unknown, although there are many Some experts believe chronic fatigue syndrome might be triggered by a combination of factors. But in several articles, Epstein Barr became the first suspect of the cause.

There are three category to diagnose chronic fatigue syndrome.
1. The fatigue significantly disturbs the work and the daily activity.
2. The fatigue has lasted for six or more consecutive months that is not related with ongoing exertion or other medical conditions.
3. The patients concurrently has at least four or more of the following eight symptoms.
a. post-exertion malaise lasting more than 24 hours
b. unrefreshing sleep
c. significant impairment of short-term memory or concentration
d. muscle pain
e. pain in the joints without swelling or redness
f. headaches of a new type, pattern, or severity
g. tender lymph nodes in the neck or armpit
h. a sore throat that is frequent or recurring

Epstein barr virus; Chronic fatigue syndrome.

Both terms always associated as a cause and a result. Some studies mentioned Epstein barr virus as the first suspect to cause chronic fatigue syndrome. Two other cause to be considered are Human herpes virus 6, and enterovirus.
Anyway, the relation of Epstein barr virus and chronic fatigue syndrome has not fully understood. A lot of researcher have studied the possibility of a single type infection might become the cause of CFS. And to date, they not found a strong evidence that Epstein Barr can cause Chronic fatigue syndrome. Perhaps, it is because the symptoms of infectious mononucleosis is similar with Chronic fatigue syndrome, so, many researcher think so.

Epstein Barr Virus Symptoms

Epstein barr virus symptoms are usually mild and sometimes without symptoms as well. However, once someone get infected by Epstein Barr Virus (EBV), the virus will persist in the body for life.

Epstein Barr virus symptoms can include :

• fatigue
• fever
• inflamed throat
• swollen lymph nodes in the neck
• enlarged spleen
• swollen liver
• rash
Almost 95 percent of people in the world has infected by EBV. It is according to study of Boston University. How to confirm that someone has got infected, while they have no Epstein barr virus symptoms? It is simple. We can check by laboratory test. The name is EBV test. It will detect the antibody VCA IgG, VCA IgM, and EBNA.
EBV is easy to spread because the symptoms is mild or sometimes without symptoms. It spreads by saliva through kissing or sharing food. That is why mononucleosis in which EBV as the main cause, is referred to as kissing disease.
Epstein Barr Virus symptoms will appear about four to six weeks after infection. Infectious mononucleosis is the main disease. But several studies have showed that there are some diseases can be associated with this virus.
Small number of patients have neurological complications. Enchepalitis, meningitis, infection of the spinal cord have been reported. But most patients with this neurological complications completely recover.
Several studies have associated Epstein Barr Virus with some cancer. Burkitt Lymphoma, Nasopharyngeal cancer, Hodgkin lymphoma, gastic cancer have been found to be related with EBV. However, the exact mechanism is not fully understood.
So, what can we do as a patient if we get Epstein Barr Virus symptoms? I think the best thing to do is not to be so worried about that. In fact, almost all people have got infected and it is always mild. Similar with influenza virus symptoms. You can consult to the doctor. Perhaps, the medical doctor will give some medicines to relieve the symptoms. Anyway, Most of the symptoms will relieve by itself, just like influenza virus. But symptomatica medicines is helpful enough to make you comfortable.

EBV Test, Is it important?

EBV Test is a laboratory test to check if someone have ever got infected by Epstein Barr Virus or not. The test is using EBV antibodies. It detects the presence of EBV antibody in your body. What is the principle?
Antibodies are the proteins that produced by your immune systems to against the harmful substance from outside of your body, called antigen. Everytime, certain antigen attack our body, our immune system will produce certain antibody to protect our body. Sometimes it win, but sometimes it can lose to against the antigen. When Epstein Barr virus infect our body, our B lymphosite will produce several antibody. There are three antibodies that can be detected after the infection. Viral Capsid antigen (VCA) IgG, VCA IgM, and Epstein Barr nuclear antigen (EBNA). These are what EBV test will detect.
The presence of these antibodies will live at long time. So, the result of EBV test is not always about current infection. Perhaps the infection has happened at previous year, and it is still detected. If you want to know the about the current infection, you can see only from one indicator. That is, VCA IgM antibodies are present and antibody to EBNA are absence. Antibody to EBNA will develop after 6 to 8 weeks after the first time of infection.
According to Boston studies, almost 95 of all people over the world have got infected by EBV. It infect in silent condition, because no symptoms or just mild symptoms show up when the infection happened. So people always don’t notice about this. So, sometimes, this EBV test is questioned. Is this important thing to perform or not.

EBV test, how to perform?

EBV test is a blood test. The method to take sample is similar with other blood test when you want to do medical check up. Blood is drawn from your vein, usually from elbow. Unfortunately, at first time, very little antibodies is available in early days of infection. So, sometimes you need to repeat the blood test after 10 to 14 days.